Disc architecture
Channel geometry, chamber volumes, capillary valves, siphons, waste handling, balance, and spin protocol.
Centrifugal microfluidic platform
Platform concept — in developmentInvertaDx
An origami-inspired lab-on-disc concept exploring how staged fluid handling, centrifugal actuation, and compact readout could support diagnostic-assay research in resource-constrained settings.
Early-stage research concept only. InvertaDx is not a finished or commercially available product and has no established analytical, clinical, regulatory, or manufacturing performance.
Development question
Can a compact disc organize multiple assay steps with fewer manual transfers?
The concept brings sample entry, staged reagent handling, separation, washing, mixing, waste capture, and measurement regions into one centrifugal architecture.
The “origami” direction refers to folding or layered construction approaches that may help organize channels and chambers while keeping early prototypes accessible. Final materials, fabrication method, assay chemistry, and readout remain to be defined and tested.
Proposed assay path
A staged centrifugal workflow
The source concept drawing suggests the following functional sequence. It is a development hypothesis, not a verified operating protocol.
- 01
Load
Introduce sample and dilution inputs into defined disc regions.
- 02
Separate
Use centrifugal forces and chamber geometry to support plasma or sample-fraction preparation.
- 03
Process
Sequence mixing, magnetic-particle handling, washing, and reagent-contact steps.
- 04
Read
Route final assay material toward measurement cuvettes or another application-specific detection region.
System definition
What the platform would need to resolve
Assay integration
Sample type, separation performance, reagent storage, particle handling, incubation timing, and detection chemistry.
Instrument interface
Motor control, disc registration, enclosure, power, sensing, optical readout, and software-guided operation.
Evidence plan
Fluidic visualization, recovery measurements, contamination checks, repeatability, analytical comparison, and failure-mode testing.
Concept architecture
Disc, actuation, readout, and documented evidence
A useful platform must connect physical fluid handling to a repeatable operating method and inspectable data.
SampleDefined input and preparation requirements
DiscLayered channels, chambers, valves, and waste
Spin controlProgrammed acceleration, hold, and deceleration steps
ReadoutApplication-specific optical or sensor measurement
Development status
What is documented, and what is still open
Documented concept: an origami-based lab-on-disc direction, a proposed multi-chamber disc layout, a compact enclosure idea, and a visual demonstration of delayed lateral flow.
Open engineering work: requirements, materials, detailed CAD, spin profile, valve characterization, cartridge-to-instrument interface, and repeatable prototype fabrication.
Open assay work: target assay, reagents, sample preparation, analytical controls, readout method, calibration, interference testing, and comparison studies.
Source: technical wording and concept artwork were adapted from the earlier MicroCD Labs Google Site. Personal details were intentionally excluded.
Potential development fit
A platform program, not a single component
Fluidic developmentTranslate the proposed sequence into channels, chambers, valves, spin steps, and test articles.
Instrument integrationCoordinate motor control, mechanical registration, enclosure, sensing, readout, and operator workflow.
Verification planningDefine measurable fluidic, assay, usability, and repeatability questions before expanding claims.
Research and development
Discuss a lab-on-disc development question.
MicroCD Labs welcomes non-confidential conversations about centrifugal fluidics, assay integration, disc prototyping, spin-control workflows, and research readout strategies.
Please do not submit patient information, protected health information, trade secrets, unpublished results, or controlled technical data in an initial message.
Start with the intended sample, assay steps, desired output, current evidence, and the technical decision that needs to be made next.